Lyophilization also called as freeze drying is a process of dehydration of samples, commonly used to preserve perishable substances. In pharmaceutical industries, it is used to concentrate and stabilize products into powder form. The process consists of four stages- lyophilization pretreatment, freezing the compound, primary drying process, secondary drying. Pretreating the products includes concentrating the product and formulation to increase the surface area. Once the product is pretreated, it is frozen using methanol or liquid nitrogen. At this stage, the compound is cooled below its triple point which is the lowest temperature at which the vapor, liquid and solid state co-exist. In the next stage of primary drying, the pressure is reduced so that water in the compound sublimates. In the last stage, the unfrozen water molecules are removed by increasing the temperature to near 0 degrees and lowering pressure for desorption.
Lyophilization is an effective preservation process and stabilization of compounds such as proteins, peptides, vaccines, blood fractions, enzymes, microbes, nutraceuticals and other biopharmaceutical products. They help in extending the shelf life while maintaining the functionality and integrity of the biomolecules. Due to reduction of storage space and weight, they also make the handling easier and avoid the need of cold storage.
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Lyophilization market can be segmented based on product type as follows:
- Lyophilization units
- Manifold freeze dryer
- Rotary freeze dryer
- Tray style freeze dryer
- Lyophilization services
The lyophilization market will be driven by its wide scope of application, the advances in the pharmaceutical industry such as new drug discovery and technological advances in the lyophilization methods such as computer controlled process and automation in loading and unloading by robotics. These augmentations will make the overall process easier and will help in expanding the scope of application. The lyophilization instruments are expensive and high electricity consumption unit. Apart from these factors the process time for lyophilization is also long. But considering the merits, the restraints do not drastically affect the market growth.
Some of the key players in the lyophilization units market are ABB Ltd., W.L. Gore & Associates, Inc. and GEA Niro while Lyophilization Technology, Inc., GenScript, Inc. Irvine Pharmaceutical Services are some of the pyophilization services providers.
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Geographies analyzed under this research report include
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- Asia Pacific
- Rest of the World
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